![]() ![]() The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial The randomization master list will be kept with the investigator and both patients and physician will be blinded to the treatment received. ![]() The investigators will perform block randomization of the subjects in blocks of 4 in the ratio of 1:1 such that 2 will be assigned to treatment and 2 will be assigned to placebo. Enrolment and assignment of intervention will be carried out by an investigator. Participants will be randomised using block randomization by a pre-determined randomisation schedule generated by a biostatistician in block size of 4. This is a double-blinded randomised control trial. Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information This suggests that BSYJ pills possibly works on improving the motility of the sperms in patients having the Kidney deficiency body constitution.Īs such, this study aims to validate these hypotheses and anecdotal evidence by conducting a safety and efficacy study of the BSYJ pill on a prospective cohort. In a subgroup of patients where serial sperm analysis was available (n=10), the percentage of sperm with grade A motility increased from a median of 22.6 ± 2.4% pre-treatment to 35.1 ± 3.2% post treatment (p < 0.05) and the hyaluronic binding assay improved from 33.2 ± 2.4% to 72 ± 4.6% (p < 0.05). One such option is the Bu Shen Yi Jing (BSYJ) pill.Ī clinical observational study conducted by the team in Singapore Thong Chai Medical on subfertile male patients with poor sperm quality and a body constitution of Kidney Deficiency showed that 2 courses of BSYJ pill over a 6 months' duration resulted in successful conception of 33% of azoospermic male patients (n = 60). Given the lack of proven treatment options in Western Medicine, Traditional Chinese Medicine (TCM) may provide a viable complementary treatment option. All assisted reproduction treatments are associated with medical, financial and emotional burden. When treatment fails, assisted reproduction will be the last resort. Various antioxidant formulations and multivitamins have been used empirically but have not been shown consistently to improve sperm counts and viability. There is a paucity of studies and randomized controlled trials to guide treatment of male factor subfertility. The majority of men who present with subfertility have either abnormal sperm density, motility or morphology, or a combination of the above, and treatment for this condition is varied and empirical. With increasing paternal age, semen volume, sperm motility and the percentage of sperm with normal morphology decreases. Impaired fertility affects 10 to 15% of couples and male factor is the cause of subfertility in 25 to 40% of couples. Subfertility is defined as a failure to conceive after 1 year of regular unprotected intercourse. ![]() Why Should I Register and Submit Results?. ![]()
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